Description

n-Methylnaltrindole is a potent and highly selective antagonist of the delta opioid receptor (DOR). This compound is a critical research tool for elucidating the complex roles of the opioid system in pain modulation, addiction, and neurological disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and clinical researchers focused on developing novel therapeutic agents and understanding neuropharmacology.

Application

• Neuroscience Research: A key pharmacological tool for studying delta opioid receptor (DOR) function and signaling pathways in the central and peripheral nervous systems.
• Pain Mechanism Studies: Used to investigate the specific role of DOR in pain perception, analgesia, and the development of tolerance to mu-opioid agonists.
• Drug Addiction Research: Employed in preclinical models to explore DOR's involvement in reward, reinforcement, and relapse behaviors associated with substance abuse.
• Neuropsychiatric Disorder Models: Applied in research on depression, anxiety, and Parkinson's disease where the opioid system is implicated.
• Pharmacological Profiling: Serves as a reference standard for screening and characterizing new chemical entities targeting opioid receptors.
• Clinical Research Support: Supports translational studies aiming to develop DOR-targeted therapies for chronic pain management with reduced side-effect profiles.

Basic Information

Product Name	n-Methylnaltrindole
CAS No.	111555-57-8
Molecular Formula	C28H31NO4
Molecular Weight	445.55 g/mol
Synonyms	MNTI; Methylnaltrindole; 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan; N-Methylnaltrindole; 5'-Methylnaltrindole; N-Methyl-naltrindole; δ-Opioid receptor antagonist
EINECS	Contact for details

Quality Control

Our n-Methylnaltrindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, identity verification by spectroscopic methods (IR, NMR), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.