Description

Combretastatin A-3 is a potent, naturally occurring stilbenoid compound originally isolated from the South African bush willow, *Combretum caffrum*. This molecule serves as a critical lead compound and reference standard in pharmaceutical research, particularly for its role as a tubulin polymerization inhibitor. It is essential for researchers and developers in the fields of oncology and vascular biology, where it is used to study anti-angiogenic mechanisms and develop novel chemotherapeutic agents. The compound's unique structure makes it a valuable building block for synthesizing more potent derivatives, such as Combretastatin A-4 phosphate.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method validation in drug discovery and development.
• Anti-Cancer Research: Serves as a key biological tool to study the inhibition of tubulin polymerization and its effects on disrupting tumor vasculature (anti-angiogenesis).
• Lead Compound for Drug Design: Acts as a structural template for the synthesis and optimization of novel vascular disrupting agents (VDAs) and anti-mitotic drugs.
• Biochemical Assays: Employed in *in vitro* and cell-based assays to investigate cytoskeleton dynamics, cell cycle arrest, and apoptosis.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in chemical biology and experimental therapeutics.
• Preclinical Development: Supports pharmacokinetic, pharmacodynamic, and toxicology studies for next-generation chemotherapeutic candidates.

Basic Information

Item	Details
Product Name	Combretastatin A-3
CAS No.	111394-45-7
Molecular Formula	C17H18O5
Molecular Weight	302.32 g/mol
Synonyms	Combretastatin A3; (Z)-3,4',5-Trimethoxy-3'-hydroxystilbene; 3'-Hydroxy-3,4,5-trimethoxystilbene; 1-(3-Hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene; CA3; NSC 617754
EINECS	Contact for details

Quality Control

Our Combretastatin A-3 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, ensuring reliable and reproducible results for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.