Description

Napyradiomycin B4 is a specialized secondary metabolite belonging to the napyradiomycin class of compounds, known for its unique halogenated meroterpenoid structure. This compound is of significant interest in pharmaceutical research and development due to its potent biological activities, particularly its antimicrobial and anticancer properties. It serves as a critical reference standard and a promising lead compound for researchers in drug discovery, synthetic biology, and natural product chemistry.

Application

• Pharmaceutical Research & Development: As a key reference standard for the identification, quantification, and purity assessment of napyradiomycin analogs in drug discovery pipelines.
• Antimicrobial Agent Studies: Investigation of its mechanism of action and efficacy against drug-resistant bacterial strains, including MRSA.
• Oncology Research: Evaluation of its cytotoxic and anticancer activities in various in vitro and in vivo model systems.
• Natural Product Synthesis: Serving as a complex target molecule for total synthesis projects and the development of novel synthetic methodologies.
• Biochemical Pathway Analysis: Used in studies to elucidate biosynthetic pathways in Streptomyces and other actinomycetes.
• High-Throughput Screening (HTS): Incorporated into compound libraries for screening against novel biological targets.

Basic Information

Product Name	Napyradiomycin B4
CAS No.	111216-63-8
Molecular Formula	C23H29ClO5
Molecular Weight	420.93 g/mol
Synonyms	Napyradiomycin B4; Antibiotic A 80915 B; Napyradiomycin B 4; 8-Chloro-7,10-dihydroxy-6-methoxy-3-methyl-1-oxo-1H-2-benzoxacyclododecine-5-carboxylic acid, 10,11-didehydro-9,10-dideoxy-9,10-[methanomethano[1,2]benzeno]-, (3R,5R,9S,10R)-
EINECS	Contact for details

Quality Control

Our Napyradiomycin B4 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant standards for high-purity research chemicals to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. The compound is hygroscopic; ensure the container is sealed in a dry environment to minimize moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.