Description

8-Deazahomofolic Acid is a specialized heterocyclic compound and a structural analog of folic acid. This high-purity intermediate is critical for advanced research and development in medicinal chemistry, particularly in the synthesis of novel enzyme inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing targeted therapeutics. The compound offers a unique scaffold for investigating biochemical pathways related to folate metabolism.

Application

• Pharmaceutical Research Intermediate: Serves as a key building block in the synthesis of potential antifolate and anticancer agents.
• Biochemical Probe Development: Used to study enzymes in the folate pathway, such as dihydrofolate reductase (DHFR) and thymidylate synthase.
• Medicinal Chemistry: Provides a core structure for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Academic Research: Utilized in university and institutional labs for fundamental studies in chemical biology and enzymology.

Basic Information

Product Name	8-Deazahomofolic Acid
CAS No.	111113-73-6
Molecular Formula	C₂₀H₂₃N₇O₅
Molecular Weight	441.45 g/mol
Synonyms	8-Deaza-4-amino-4-deoxypteroylglutamic acid; 8-Deazaaminopterin glutamic acid; Homofolic acid, 8-deaza-; L-Glutamic acid, N-[4-[[(2-amino-8-deaza-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino]benzoyl]-; 8-Deaza-4-aminofolic acid
EINECS	Contact for details

Quality Control

Our 8-Deazahomofolic Acid is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality control includes identification by spectroscopic methods, purity assessment by HPLC, and control of related substances. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.