Description

n-Desmethyltoremifene is a key pharmaceutical intermediate and active metabolite of the selective estrogen receptor modulator (SERM) toremifene. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis and study of advanced anti-estrogen therapies. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and hormone-related research.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of toremifene and related SERM compounds.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and formulation of novel anti-estrogen drug candidates.
• Metabolite Reference Standard: Serves as an analytical standard in bioanalytical studies for pharmacokinetic and metabolic profiling of toremifene.
• Biochemical Research: A tool compound for studying estrogen receptor (ER) binding affinity, selectivity, and downstream signaling pathways in vitro.
• Oncology R&D: Investigated for its potential therapeutic effects in hormone-sensitive cancers, including breast cancer.

Basic Information

Product Name	n-Desmethyltoremifene
CAS No.	110503-61-2
Molecular Formula	C25H27NO2
Molecular Weight	373.49 g/mol
Synonyms	4-[(Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenol; FC-1271a; Desmethyltoremifene; Toremifene Metabolite; (Z)-4-(1-(4-Chlorophenyl)-2-phenyl-1-buten-1-yl)phenol; 4-[(1Z)-1-(4-Chlorophenyl)-2-phenyl-1-buten-1-yl]phenol; 110503-61-2
EINECS	Contact for details

Quality Control

Our n-Desmethyltoremifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.