Description

3,5-Difluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoro and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronics: Acts as a monomer or intermediate in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Functional Material Development: Employed in research to create novel polymers, coatings, and specialty chemicals with unique surface properties and chemical resistance.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	3,5-Difluorobenzotrifluoride
CAS No.	110499-76-8
Molecular Formula	C7H3F5
Molecular Weight	194.09 g/mol
Synonyms	1,3-Difluoro-5-(trifluoromethyl)benzene; 3,5-Difluoro-α,α,α-trifluorotoluene; 3,5-Difluoro(trifluoromethyl)benzene; α,α,α,3,5-Pentafluorotoluene; Benzene, 1,3-difluoro-5-(trifluoromethyl)-; 3,5-Difluorobenzyl trifluoride; 3,5-Difluorophenyl trifluoromethane
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-25°C. The container should be kept tightly sealed to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Density (at 20°C)	~1.45 g/mL
Refractive Index (n20D)	~1.40

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.