Description

Dolastatin 10 is a potent, naturally occurring antimitotic pentapeptide originally isolated from the marine sea hare Dolabella auricularia. This compound matters as a highly significant lead molecule in oncology research, serving as a benchmark for the development of novel antibody-drug conjugates (ADCs) and targeted cancer therapies. Pharmaceutical researchers, medicinal chemists, and biotech companies engaged in preclinical and clinical development of next-generation cytotoxins need this high-purity reference standard.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for quality control and method validation in ADC and oncology drug development.
• Biomedical Research: Used as a critical tool compound in mechanistic studies of tubulin polymerization inhibition and apoptosis induction.
• Lead Compound for ADC Development: Acts as the cytotoxic warhead prototype for designing and synthesizing novel, targeted drug conjugates with improved therapeutic indices.
• Preclinical Evaluation: Employed in in vitro and in vivo studies to assess antitumor efficacy and pharmacokinetic profiles of new chemical entities.
• Structure-Activity Relationship (SAR) Studies: Provides the foundational chemical scaffold for synthesizing and testing analogs to optimize potency and reduce toxicity.

Basic Information

Product Name	Dolastatin 10
CAS No.	110417-88-4
Molecular Formula	C42H66N6O6
Molecular Weight	774.99 g/mol
Synonyms	Dolastatin-10; (3S,6S,9S,12R,21S,24S,27S,30S,33S)-27-[(1S)-1-Amino-2-methylpropyl]-33-[(2S)-butan-2-yl]-12,21,24,30-tetramethyl-3,6,9,15,18,21,24,27,30,33,36-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotetratriacontane-4,7,10,16,19,22,25,28,31-nonaen-1-ium; NSC-376128; Auristatin PE; TZT-1027
EINECS	Contact for details

Quality Control

Our Dolastatin 10 is produced under strict quality management systems to ensure the highest standards of purity and consistency required for research and development. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS, NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.