Description

Cki-8 is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2), a key regulator of the cell cycle. This compound is a vital research tool for studying cell cycle progression, proliferation, and apoptosis in various biological systems. It is primarily utilized by researchers and scientists in the fields of oncology, biochemistry, and molecular biology for target validation and drug discovery efforts. The product is supplied under the identifier Cki-8 CAS NO 110408-10-1.

Application

• Biochemical Research: Used as a selective CDK2 inhibitor to study cell cycle regulation, signal transduction pathways, and protein kinase function in vitro.
• Cancer Research: A critical tool for investigating the role of CDK2 in tumor cell proliferation and for evaluating potential anti-cancer therapeutic strategies.
• Pharmacology Studies: Employed in high-throughput screening and lead optimization processes during the development of novel kinase-targeted pharmaceuticals.
• Academic Research: Supports fundamental studies in universities and research institutes focused on cell biology, genetics, and developmental processes.
• Assay Development: Serves as a reference standard and positive control in enzymatic assays designed to measure CDK2 activity.

Basic Information

Product Name	Cki-8
CAS No.	110408-10-1
Molecular Formula	C₁₄H₁₂N₄O₂
Molecular Weight	268.27 g/mol
Synonyms	2-((2-Hydroxyethyl)amino)-6-benzylamino-9-isopropylpurine; 6-Benzylamino-2-((2-hydroxyethyl)amino)-9-isopropylpurine; CDK2 Inhibitor III; Cdk2 Inhibitor; CKI-8; CKI 8
EINECS	Contact for details

Quality Control

Our Cki-8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure high batch-to-batch consistency and reliability for research applications. A detailed Certificate of Analysis (COA) containing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.