Description

Oligomycin E is a potent and specific inhibitor of the mitochondrial F1Fo-ATP synthase complex. This compound matters for researchers as a critical tool for studying cellular bioenergetics, oxidative phosphorylation, and ATP-dependent processes. It is primarily needed by the life science research community, pharmaceutical discovery units, and academic institutions focused on metabolism, cancer biology, and mitochondrial dysfunction.

Application

• Mitochondrial Research: A key pharmacological tool for inhibiting ATP synthase to study mitochondrial respiration, membrane potential, and bioenergetic profiles in cells.
• Cancer Biology Studies: Used to investigate the role of oxidative phosphorylation in cancer cell proliferation, survival, and the Warburg effect.
• Metabolic Pathway Analysis: Essential for elucidating ATP-dependent pathways and understanding metabolic shifts under various physiological and pathological conditions.
• Pharmacological Profiling: Serves as a reference standard in screening assays for compounds targeting mitochondrial function or energy metabolism.
• Biochemical Assay Development: Employed in the development and validation of in vitro assays measuring ATP production, oxygen consumption rate (OCR), and glycolytic flux.
• Neurodegenerative Disease Research: Applied in models studying mitochondrial impairment associated with diseases like Parkinson's and Alzheimer's.

Basic Information

Product Name	Oligomycin E
CAS No.	110231-34-0
Molecular Formula	C45H74O12
Molecular Weight	791.1 g/mol
Synonyms	Oligomycin E; Oligomycin A, 26-deoxy-; 26-Deoxyoligomycin A; Oligomycin A 26-deoxy-; Oligomycin E (26-Deoxyoligomycin A); Antibiotic X-537A factor E; 110231-34-0; Oligomycin E from Streptomyces
EINECS	Contact for details

Quality Control

Our Oligomycin E is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, assay results, and storage conditions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, solutions should be prepared in anhydrous solvents and stored under inert atmosphere at -80°C. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, ethanol, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.