Description

Calpain Inhibitor II is a potent, cell-permeable inhibitor of the calcium-dependent cysteine proteases calpain I and II. This compound is critical for researchers investigating the role of calpain in cellular processes such as apoptosis, signal transduction, and neurodegeneration. It is an essential biochemical tool for pharmaceutical R&D, academic research in neuroscience and cell biology, and the development of therapeutic strategies for conditions like muscular dystrophy and ischemic injury.

Application

• Biochemical Research: A fundamental tool for studying calpain-mediated proteolysis in in vitro and cell-based assays.
• Neuroscience Studies: Used to investigate the role of calpain activation in neurodegenerative diseases, stroke, and traumatic brain injury models.
• Cardiovascular Research: Applied in studies of myocardial ischemia-reperfusion injury and other calpain-involved cardiac pathologies.
• Muscle Biology: Essential for research into muscular dystrophy and other disorders involving calpain-3 (p94).
• Pharmaceutical Screening: Serves as a reference compound and positive control in high-throughput screening for novel calpain inhibitors.
• Apoptosis & Cell Signaling: Utilized to dissect the contribution of calpain to programmed cell death and signal transduction pathways.

Basic Information

Product Name	Calpain Inhibitor II
CAS No.	110115-07-6
Molecular Formula	C₂₀H₃₈N₄O₄
Molecular Weight	398.54 g/mol
Synonyms	ALLN; N-Acetyl-Leu-Leu-Norleucinal; Ac-LLN-CHO; Calpain Inhibitor I; MDL 28170; Z-LLN-CHO; N-Acetyl-Leu-Leu-Nle-al; (2S)-2-Acetamido-4-methyl-N-[(2S)-1-[[(2S)-1-[[(2S)-1-oxo-1-[(2S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-yl]pentan-2-yl]amino]-4-methylpentan-2-yl]amino]-1-oxopentan-2-yl]pentanamide
EINECS	Contact for details

Quality Control

Our Calpain Inhibitor II is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical quality attributes to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Biological Activity (IC₅₀ Calpain I)	≤ 200 nM
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.