Description

n-Desmethyl-4-Hydroxy Tamoxifen (Approx. 1:1 E/Z Mixture) is a key active metabolite and reference standard of the selective estrogen receptor modulator (SERM) Tamoxifen. This compound is of critical importance for pharmaceutical research and development, particularly in the study of Tamoxifen's metabolic pathways, efficacy, and safety profile. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development, bioanalytical method validation, and metabolite identification studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of Tamoxifen and its metabolites in drug substances and biological matrices.
• Metabolite Research: Essential for pharmacokinetic and pharmacodynamic studies to understand the in vivo activity and clearance of Tamoxifen.
• Bioanalytical Method Development: Used in the development and validation of HPLC, LC-MS, and LC-MS/MS methods for therapeutic drug monitoring and clinical studies.
• Drug Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of Tamoxifen-based drug products.
• Biochemical Assays: Employed in in vitro assays to study estrogen receptor binding affinity and the mechanistic action of SERMs.
• Academic and Preclinical Research: Supports fundamental research in breast cancer endocrinology and the development of next-generation hormone therapies.

Basic Information

Product Name	n-Desmethyl-4-Hydroxy Tamoxifen (Approx. 1:1 E/Z Mixture)
CAS No.	110025-28-0
Molecular Formula	C25H27NO2
Molecular Weight	373.49 g/mol
Synonyms	4-Hydroxynor-Tamoxifen; (Z)-4-Hydroxynor-Tamoxifen; (E)-4-Hydroxynor-Tamoxifen; 4-Hydroxy-N-desmethyltamoxifen; Endoxifen Impurity; Tamoxifen Metabolite Y; Tamoxifen Metabolite B; Afimoxifene Impurity
EINECS	Contact for details

Quality Control

Our n-Desmethyl-4-Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, chiral/isomeric ratio confirmation (E/Z mixture), and identity verification by spectroscopic methods. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isomeric Ratio (E/Z)	Approx. 1:1 (by HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.