Description

4-Fluoroenisoprost is a fluorinated analog of enisoprost, a synthetic prostaglandin E1 derivative. This structural modification enhances its metabolic stability and receptor binding affinity, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents targeting gastrointestinal, cardiovascular, and ophthalmic conditions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated prostaglandin analogs with improved pharmacokinetic profiles.
• Biochemical Research: Used as a reference standard and probe compound in studies of prostaglandin receptor (EP receptor) pharmacology and signal transduction pathways.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new anti-ulcer, cytoprotective, or vasoactive drugs.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for prostaglandin-based active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for investigating the structure-activity relationships (SAR) of eicosanoids.

Basic Information

Product Name	4-Fluoroenisoprost
CAS No.	109976-45-6
Molecular Formula	C23H37FO5
Molecular Weight	412.54 g/mol
Synonyms	4-Fluoroenisoprost; 4-Fluoro Enisoprost; 9-Deoxo-9,10-didehydro-4-fluoromisoprostol; 4-Fluoromisoprostol analog; SC-34301; Fluoroenisoprost; Prostaglandin E1 fluorinated analog; (Z)-7-[(1R,2R,3R,5S)-2-[(E,3S)-3-Fluoro-4-phenoxy-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoroenisoprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.