Description

Combretastatin A1 is a potent, naturally occurring stilbenoid compound originally isolated from the African bush willow, *Combretum caffrum*. It serves as a critical research tool and a lead compound in the development of novel vascular-targeting agents for oncology. This molecule is of significant interest to pharmaceutical researchers and developers focused on anti-cancer therapeutics, particularly in the study of tumor vasculature disruption. Its unique mechanism of action makes it a valuable asset for preclinical studies and drug discovery pipelines.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate in the development of vascular-disrupting agents (VDAs).
• Preclinical Oncology Studies: Used in *in vitro* and *in vivo* models to investigate mechanisms of action related to tubulin binding and inhibition of tumor blood flow.
• Lead Compound Optimization: Serves as a structural template for the synthesis and evaluation of more stable, potent, or bioavailable analogs and prodrugs.
• Biochemical Assays: Employed in high-throughput screening (HTS) and target validation studies to identify and characterize new anti-mitotic compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, angiogenesis, and cancer pathology.

Basic Information

Product Name	Combretastatin A1
CAS No.	109971-63-3
Molecular Formula	C18H20O5
Molecular Weight	316.35 g/mol
Synonyms	Combretastatin A-1; (Z)-1-(3,4,5-Trimethoxyphenyl)-2-(3-hydroxy-4-methoxyphenyl)ethene; 3'-Hydroxy-3,4,4',5-tetramethoxy-(Z)-stilbene; CA1; CA-1; Combretastatin A 1; NSC-706788
EINECS	Contact for details

Quality Control

Our Combretastatin A1 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research purposes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While we offer material suitable for research use, we adhere to principles of current Good Manufacturing Practice (cGMP) for advanced intermediates to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.