Description

2-Chloro-3-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents adjacent to a trifluoromethyl group, makes it a key intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Serves as a core building block for novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the fluorine atoms.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Acts as a monomer or modifier to introduce fluorine into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying structure-activity relationships and developing new fluorination methodologies.

Basic Information

Product Name	2-Chloro-3-Fluorobenzotrifluoride
CAS No.	109957-97-3
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2-fluoro-3-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-3-fluorotoluene; 3-Fluoro-2-chlorobenzotrifluoride; 2-Chloro-3-fluorobenzylidene trifluoride; 2-Chloro-3-(trifluoromethyl)fluorobenzene; Benzene, 1-chloro-2-fluoro-3-(trifluoromethyl)-; 3-Fluoro-2-chloro-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.