Description

Tautomycin is a potent and selective inhibitor of protein phosphatases PP1 and PP2A, originally isolated from *Streptomyces spiroverticillatus*. This compound is a critical biochemical tool for studying cellular signaling pathways, particularly those involving serine/threonine dephosphorylation. It is essential for researchers and developers in the fields of cell biology, signal transduction research, and oncology drug discovery, where precise modulation of phosphatase activity is required.

Application

• Biochemical Research: A fundamental tool for in vitro and cellular studies to inhibit PP1 and PP2A, elucidating their roles in cell cycle regulation, apoptosis, and metabolism.
• Signal Transduction Studies: Used to investigate phosphorylation/dephosphorylation cascades in various disease models, including cancer and neurodegenerative disorders.
• Pharmaceutical Development: Serves as a reference compound and a starting point for the development of novel therapeutic agents targeting phosphatase pathways.
• Agricultural Research: Applied in studies exploring plant physiology and stress responses where protein phosphatases play a regulatory role.
• Academic & Institutional Labs: A standard reagent for graduate and post-doctoral research in molecular biology and pharmacology departments worldwide.

Basic Information

Product Name	Tautomycin
CAS No.	109946-35-2
Molecular Formula	C₄₃H₆₇NO₁₄
Molecular Weight	846.0 g/mol
Synonyms	Tautomycin; Antibiotic Tautomycin; [1R-(1R*,4E,7S*,8S*,9R*,10S*,11R*,12R*,13S*)]-7,9,11,13-Tetramethyl-16-oxo-15-oxabicyclo[10.2.1]pentadeca-4,8-diene-5-carboxylic Acid 10-(2,4-Dimethyl-1-oxo-1,3-butadien-1-yl)-9,11-dihydroxy-8-methyl-4,6,12,14-tetraoxo-3-(1-oxopropyl)-2-oxa-5,13-diazapentadec-14-en-1-yl Ester; (2S)-2-[(2S)-2-[(2S,3S,6R)-6-[(1E,3E)-4-[(1S,2S,4S,5R,6S,8R,9S,10S,12S,13R,15R)-5,9,13-Trihydroxy-2,4,8,10,12,15-hexamethyl-3,7,11-trioxo-16-oxabicyclo[10.2.1]pentadeca-1(14),4-dien-6-yl]-3-methylbuta-1,3-dien-1-yl]-3-methyl-5-oxotetrahydro-2H-pyran-2-yl]-3-methylbutanoyl]oxy]-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our Tautomycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.