Description

Cgs 9343B is a selective and potent inhibitor of calmodulin-dependent enzymes, specifically protein kinase II (CaMKII). This compound is a critical research tool for studying intracellular calcium signaling pathways and their role in various physiological and pathological processes. It is primarily utilized by researchers and scientists in the fields of biochemistry, neuroscience, and pharmacology for in vitro and ex vivo studies.

Application

• Biochemical Research: A key reagent for investigating the mechanisms of calcium/calmodulin-dependent protein kinase II (CaMKII) in signal transduction.
• Neuroscience Studies: Used to explore the role of CaMKII in synaptic plasticity, memory formation, and neuronal excitability.
• Cardiovascular Research: Employed in studies examining calcium signaling in cardiac muscle contraction and vascular tone regulation.
• Cellular Pathway Analysis: Facilitates the dissection of downstream effects of calmodulin activation in various cell types.
• Drug Discovery: Serves as a reference compound and pharmacological tool in screening assays for novel CaMKII inhibitors.
• Academic & Institutional Labs: Essential for basic research in university and government research institutions worldwide.

Basic Information

Product Name	Cgs 9343B
CAS No.	109826-27-9
Molecular Formula	C20H21N3O3
Molecular Weight	351.40 g/mol
Synonyms	1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine; CGS 9343B; CGS-9343B; CaMKII Inhibitor CGS 9343B; 1-[(4-Fluorophenyl)(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
EINECS	Contact for details

Quality Control

Our Cgs 9343B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.