Description

n-Fluoro-3,5-Dichloropyridinium Tetrafluoroborate is a highly reactive electrophilic fluorinating agent. This compound matters for its ability to introduce fluorine atoms into complex organic molecules under mild conditions, a critical transformation in modern synthetic chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel fluorinated active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the late-stage fluorination of drug candidates to modulate metabolism, bioavailability, and binding affinity.
• Agrochemical Development: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials, liquid crystals, and polymers with unique properties.
• Positron Emission Tomography (PET) Tracer Labeling: Potential use in the rapid incorporation of fluorine-18 for radiopharmaceutical development.
• Academic & Contract Research: A valuable tool for methodology development and exploring new fluorination reactions in academic and CRO laboratories.
• Fine Chemical Production: Enables the manufacture of specialty fluorinated building blocks and intermediates for various high-value chemical streams.

Basic Information

Product Name	n-Fluoro-3,5-Dichloropyridinium Tetrafluoroborate
CAS No.	109705-15-9
Molecular Formula	C5H2Cl2F5NB
Molecular Weight	273.79 g/mol
Synonyms	1-Fluoro-3,5-dichloropyridinium Tetrafluoroborate; 3,5-Dichloro-1-fluoropyridinium Tetrafluoroborate; N-Fluoropyridinium Salt; Electrophilic Fluorinating Reagent; NFPy-BF4; 3,5-Dichloro-N-fluoropyridinium Tetrafluoroborate; N-Fluoro-3,5-dichloropyridinium Boron Tetrafluoride
EINECS	Contact for details

Quality Control

Our n-Fluoro-3,5-Dichloropyridinium Tetrafluoroborate is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹⁹F, ¹¹B), HPLC, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., argon or nitrogen) and opened only in a moisture-controlled environment. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.