Description

Dihydrotamoxifen is a key pharmaceutical intermediate and metabolite of the selective estrogen receptor modulator (SERM) tamoxifen. This compound is of significant importance in research and development for its role in studying tamoxifen metabolism, drug resistance mechanisms, and the development of novel SERM-based therapies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for oncology and endocrine research applications.

Application

• Pharmaceutical Intermediate: Critical synthesis precursor in the production of tamoxifen analogs and related therapeutic agents.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies to quantify tamoxifen and its metabolites in biological matrices.
• Biochemical Research: Employed in studies investigating estrogen receptor binding affinity, pharmacokinetics, and the metabolic pathways of SERMs.
• Drug Discovery & Development: Serves as a tool compound for screening and developing new generations of hormone receptor-targeting therapies.
• Quality Control & Assurance: Acts as a reference material in the quality control processes of tamoxifen API manufacturing.

Basic Information

Product Name	Dihydrotamoxifen
CAS No.	109640-20-2
Molecular Formula	C26H29NO
Molecular Weight	371.52 g/mol
Synonyms	(Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene; 1,2-Diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene; trans-Dihydrotamoxifen; (E)-Dihydrotamoxifen; ICI 47699; Metabolite B of Tamoxifen; 4-[(Z)-1,2-Diphenyl-1-butenyl]phenoxy-N,N-dimethylethanamine
EINECS	Contact for details

Quality Control

Our Dihydrotamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.