Description

Choline Chloride, [1,2-14C] CAS NO 109572-96-5 is a radiolabeled derivative of the essential nutrient choline chloride, where the carbon atoms at positions 1 and 2 are the radioactive isotope carbon-14. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling researchers to precisely track the absorption, distribution, metabolism, and excretion (ADME) of choline and its metabolites. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) engaged in advanced tracer studies, drug development, and nutritional science.

Application

• Tracer Studies in Metabolism Research: Used to elucidate the biochemical pathways of choline in lipid metabolism, neurotransmitter synthesis (acetylcholine), and one-carbon metabolism.
• Pharmacokinetic (PK) and ADME Profiling: Essential for tracking the fate of choline-containing drug candidates or nutraceuticals in preclinical and clinical research.
• Biomedical Imaging and Autoradiography: Serves as a precursor for synthesizing radiolabeled probes for imaging techniques to study organ-specific uptake and distribution.
• Nutritional and Feed Science: Applied in research to understand choline bioavailability, transport mechanisms, and its role in animal and human health.
• Environmental Fate Studies: Employed to investigate the degradation and environmental persistence of choline-based compounds.

Basic Information

Item	Details
Product Name	Choline Chloride, [1,2-14C]
CAS No.	109572-96-5
Molecular Formula	C5H14ClNO * (14C at positions 1 & 2)
Molecular Weight	~139.62 g/mol (unlabeled base)
Synonyms	(2-Hydroxyethyl)trimethylammonium chloride, [1,2-14C]; Biocolina; Hepacholine; Lipotril; 14C-Choline Chloride; Choline chloride (labeled with carbon-14); 2-Hydroxy-N,N,N-trimethylethanaminium chloride, [1,2-14C]; Vitamin B4 chloride (labeled)
EINECS	Contact for details

Quality Control

Every batch of Choline Chloride, [1,2-14C] is manufactured and analyzed under strict quality systems to ensure traceability, radiochemical purity, and specific activity consistency. Our quality commitment includes comprehensive analytical documentation. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as radiochemical purity (by HPLC), specific activity, chemical purity, and solvent content. We adhere to relevant GLP (Good Laboratory Practice) standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radioactive materials. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR/NMR)	Conforms to structure
Assay (Radiochemical Purity)	≥ 97% (by HPLC)
Specific Activity	Customizable (mCi/mmol or GBq/mmol)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Specified (e.g., Ethanol:Water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.