Description

U0126 CAS NO 109511-58-2 is a highly selective, cell-permeable inhibitor of the MEK1/2 (MAPK/ERK kinase) signaling pathway. This compound is a critical research tool for studying the role of the MAPK cascade in cellular processes such as proliferation, differentiation, and apoptosis. It is essential for researchers and developers in the fields of pharmacology, oncology, and molecular biology who require reliable, high-purity biochemical reagents for target validation and pathway analysis.

Application

• Biomedical Research: Used as a selective MEK1/2 inhibitor to study the MAPK/ERK signaling pathway in cell culture and animal models.
• Cancer Research: Investigated for its potential to inhibit the growth of various cancer cell lines where the MAPK pathway is dysregulated.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for screening and validating new therapeutic targets.
• Signal Transduction Studies: Essential for elucidating mechanisms of cellular response to growth factors, cytokines, and stress.
• Academic & Institutional Laboratories: A key reagent for graduate and post-doctoral research in biochemistry and cell biology.
• Biotech & Pharmaceutical R&D: Utilized in pre-clinical development to understand drug mechanisms and potential combination therapies.

Basic Information

Product Name	U0126
CAS No.	109511-58-2
Molecular Formula	C₁₈H₁₆N₈O₂
Molecular Weight	376.37 g/mol
Synonyms	U-0126; U 0126; 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene; 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; MEK1/2 Inhibitor U0126; MAPK Inhibitor U0126; ERK Inhibitor U0126
EINECS	Contact for details

Quality Control

Our U0126 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.