Description

Tyrosyl-Alanyl-Glycyl-N(Alpha)-Methylphenylalanine Chloromethyl Ketone is a specialized peptide-derived chloromethyl ketone, a potent and irreversible serine protease inhibitor. This compound is critical for biochemical research and pharmaceutical development, particularly in the study of enzyme mechanisms and the design of targeted therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on protease-related pathways.

Application

• Protease Inhibition Studies: Acts as an active site-directed irreversible inhibitor for characterizing serine proteases like chymotrypsin, elastase, and related enzymes.
• Biochemical Research Reagent: Used in mechanistic enzymology to study substrate specificity, catalytic mechanisms, and enzyme kinetics.
• Pharmaceutical Development: Serves as a key intermediate or pharmacophore in the design and synthesis of novel protease-targeting drug candidates.
• Proteomics & Cell Biology: Employed to selectively inhibit specific proteolytic activities in complex biological systems to elucidate their functional roles.
• Structure-Activity Relationship (SAR) Studies: Used as a template molecule for modifying peptide sequences to optimize inhibitor potency and selectivity.

Basic Information

Product Name	Tyrosyl-Alanyl-Glycyl-N(Alpha)-Methylphenylalanine Chloromethyl Ketone
CAS No.	109377-04-0
Molecular Formula	C27H33ClN4O6
Molecular Weight	545.03 g/mol
Synonyms	YAG-N(Me)F-CMK; TPCK Analog Peptide Inhibitor; Chymotrypsin Inhibitor Peptide Derivative; N-α-Methylphenylalanine Chloromethyl Ketone containing Tripeptide; Tyr-Ala-Gly-N(Me)Phe-CH2Cl; Protease Inhibitor 109377-04-0; Acetyl-Tyr-Ala-Gly-N(α-Me)Phe-chloromethyl ketone
EINECS	Contact for details

Quality Control

Our production of Tyrosyl-Alanyl-Glycyl-N(Alpha)-Methylphenylalanine Chloromethyl Ketone adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, chiral purity, and water content are provided and available upon request to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions, ideally with desiccant. For long-term stability, storage at -20°C under an inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.