Description

Taprostene is a synthetic prostaglandin analog, a potent and selective prostacyclin (PGI2) receptor agonist. This compound is of significant interest in pharmaceutical research and development due to its vasodilatory and antiplatelet aggregation properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical industry for developing novel cardiovascular therapeutics and studying vascular biology.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of new drugs targeting pulmonary arterial hypertension (PAH) and other vascular disorders.
• Cardiovascular Pharmacology Studies: Used in preclinical and clinical research to investigate mechanisms of vasodilation, platelet inhibition, and endothelial cell function.
• Biochemical Assay Development: Employed as a critical ligand in the development and validation of high-throughput screening assays for prostacyclin receptor activity.
• Metabolism and Pharmacokinetics (DMPK): Utilized as a standard in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profiles of prostacyclin analogs.
• Formulation Development: Acts as a model compound for developing stable formulations of sensitive prostaglandin-based therapeutics, addressing challenges related to oxidation and light sensitivity.

Basic Information

Product Name	Taprostene
CAS No.	108945-35-3
Molecular Formula	C21H32O5
Molecular Weight	364.48 g/mol
Synonyms	9-Deoxy-9α,11α-epoxy-13,14-dihydro-15-cyclohexyl-ω-pentanor-PGF1α; Cicaprost; ZK 96480; 15-Cyclohexyl-ω-pentanor-9-deoxy-9α,11α-epoxy-13,14-dihydro-PGF1α; Prostacyclin analog ZK 96480; Taprosten
EINECS	Contact for details

Quality Control

Our Taprostene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.