Description

Taccalonolide B is a potent, microtubule-stabilizing natural product isolated from plants of the genus *Tacca*. This compound matters as a highly specific chemical tool for cancer research, offering a unique mechanism of action distinct from other known microtubule-targeting agents. It is primarily needed by pharmaceutical R&D laboratories and academic institutions engaged in oncology research, drug discovery, and the study of cellular mitosis and cytoskeleton dynamics.

Application

• Biomedical Research: A critical reference standard and probe for studying microtubule dynamics, mitotic arrest, and mechanisms of drug resistance in cancer cell lines.
• Anticancer Drug Discovery: Serves as a lead compound and pharmacological tool for the development of novel chemotherapeutic agents with a unique binding site on tubulin.
• Mechanistic Biology Studies: Used to investigate cell cycle progression, apoptosis induction, and the functional role of the cytoskeleton in various disease models.
• High-Content Screening (HCS): Employed as a positive control in phenotypic screening assays designed to identify compounds with antimitotic activity.
• Biochemical Assay Development: Utilized in the validation and optimization of in vitro tubulin polymerization and binding assays.
• Pharmacology & Toxicology Profiling: Acts as a key compound for evaluating efficacy, potency, and therapeutic windows in preclinical studies.

Basic Information

Product Name	Taccalonolide B
CAS No.	108885-69-4
Molecular Formula	C34H50O10
Molecular Weight	618.8 g/mol
Synonyms	Taccalonolide B; NSC 654663; (1S,2R,4aS,6aR,6bS,8aS,12aS,14aR,14bS)-1,2,4a,6a,6b,9,9,12a-Octamethyl-10-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydropicene-4-carboxylic acid methyl ester; Taccalonolide-B
EINECS	Contact for details

Quality Control

Our Taccalonolide B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to relevant standards for research chemicals to guarantee identity, purity, and stability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.