Description

17-Hydroxywortmannin is a potent and specific inhibitor of phosphatidylinositol 3-kinase (PI3K) and related kinases, derived from the natural product wortmannin. This compound matters for researchers and developers as it serves as a critical biochemical tool for probing PI3K signaling pathways, which are central to cell growth, proliferation, and survival. Professionals in pharmaceutical R&D, academic biochemistry, and cell biology laboratories need it for investigating cancer mechanisms, metabolic disorders, and inflammatory diseases.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of PI3K and PI3K-related kinases (PIKKs) in cellular signaling cascades.
• Oncology Research: Employed in in vitro and cell-based assays to investigate tumor cell proliferation, survival, and drug resistance mechanisms linked to the PI3K/Akt/mTOR pathway.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for screening and validating new therapeutic agents targeting PI3K.
• Metabolic Disease Studies: Applied in research models to understand insulin signaling, glucose homeostasis, and other metabolic processes regulated by PI3K.
• Immunology & Inflammation Research: Utilized to dissect the involvement of PI3K in immune cell activation, cytokine production, and inflammatory responses.
• Neuroscience Research: Investigated for its effects on neuronal survival, synaptic plasticity, and neurodegenerative pathways where PI3K signaling is implicated.

Basic Information

Product Name	17-Hydroxywortmannin
CAS No.	108740-89-2
Molecular Formula	C23H24O8
Molecular Weight	428.43 g/mol
Synonyms	17-Hydroxywortmannin; 11β,17-Dihydroxy-3-oxoandrosta-1,4-diene-2-carboxylic Acid γ-Lactone; (11β,17β)-11,17-Dihydroxy-3-oxoandrosta-1,4-dien-2-carboxylic Acid γ-Lactone; PI3K Inhibitor (17-Hydroxywortmannin); Wortmannin, 17-hydroxy-; 17-Hydroxy-wortmannin; 17-OH-Wortmannin
EINECS	Contact for details

Quality Control

Our 17-Hydroxywortmannin is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. The container should be kept in a dry, cool, and well-ventilated area. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.