Description

(2-Bromo-1,1-Difluoroethyl)Benzene is a versatile organofluorine building block characterized by its bromine and difluoromethylene functional groups. This compound matters as a key intermediate for introducing the difluoroethyl moiety into more complex molecular architectures, enabling the fine-tuning of physical and biological properties. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoroethyl group can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its impact on molecular polarity and stability.
• Polymer & Material Science: Employed to synthesize fluorinated monomers and polymers, imparting desirable properties such as chemical resistance, low surface energy, and thermal stability.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	(2-Bromo-1,1-Difluoroethyl)Benzene
CAS No.	108661-89-8
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	α-Bromo-α,α-difluoroethylbenzene; 1-Bromo-2,2-difluoro-1-phenylethane; Benzene, (2-bromo-1,1-difluoroethyl)-; 2-Bromo-1,1-difluoro-1-phenylethane; (2-Bromo-1,1-difluoroethyl)benzene; 1-Phenylethyl-2-bromo-1,1-difluoride
EINECS	Contact for details

Quality Control

Our (2-Bromo-1,1-Difluoroethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.