Description

(Z)-N-[2-(2,5-Dihydroxyphenyl)Ethenyl]-Formamide (Cis Erbstatin) is a synthetic analog of the natural product erbstatin, functioning as a potent and selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for studying signal transduction pathways, cellular proliferation, and apoptosis in oncology and biochemistry. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer therapeutics and kinase inhibitor development.

Application

• Biochemical Research: A key tool compound for investigating EGFR-mediated signaling cascades and their role in cell growth and differentiation.
• Oncology & Cancer Research: Used in in vitro and cell-based assays to study tumor cell proliferation and to validate targets for anti-cancer drug discovery programs.
• Kinase Profiling: Serves as a reference standard in high-throughput screening (HTS) to identify and characterize new tyrosine kinase inhibitors.
• Apoptosis Studies: Employed to induce and study programmed cell death mechanisms in various cancer cell lines.
• Pharmaceutical Intermediate: Acts as a synthetic precursor or analog in the development of novel therapeutic agents targeting receptor tyrosine kinases.
• Academic Teaching & Reference: Used in advanced university laboratories for practical education in medicinal chemistry and molecular pharmacology.

Basic Information

Product Name	(Z)-N-[2-(2,5-Dihydroxyphenyl)Ethenyl]-Formamide (Cis Erbstatin)
CAS No.	108536-24-9
Molecular Formula	C9H9NO3
Molecular Weight	179.17 g/mol
Synonyms	Cis-Erbstatin; (Z)-Erbstatin; (Z)-2,5-Dihydroxy-β-formamidostyrene; (Z)-N-[2-(2,5-Dihydroxyphenyl)vinyl]formamide; EGFR Tyrosine Kinase Inhibitor (Cis-Form); NSC 377363; Erbstatin analog (cis isomer)
EINECS	Contact for details

Quality Control

Our (Z)-N-[2-(2,5-Dihydroxyphenyl)Ethenyl]-Formamide (Cis Erbstatin) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant quality management standards to support your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.