Description

Kainic Acid Dimethyl Ester Hydrochloride is a chemically modified derivative of kainic acid, a potent neuroexcitatory amino acid. This esterified hydrochloride salt is a critical research-grade biochemical used primarily in neuroscience and pharmacology to study glutamate receptor subtypes. It serves as a valuable intermediate and reference standard for the development and screening of novel neuroactive compounds targeting neurological disorders.

Application

• Neuroscience Research: A key tool compound for studying the pharmacology and physiology of kainate-type glutamate receptors (iGluRs) in the central nervous system.
• Pharmacological Screening: Used as a reference standard or intermediate in high-throughput screening assays to discover and evaluate new neuroprotective agents or receptor modulators.
• Biochemical Synthesis: Serves as a protected or modified intermediate in the synthetic pathways for more complex neuroactive molecules and labeled probes.
• Toxicology Studies: Employed in research models to induce excitotoxicity and study neuronal cell death mechanisms, aiding in the understanding of conditions like epilepsy and stroke.
• Academic & Institutional Research: Essential for university and pharmaceutical R&D laboratories focused on neurochemistry and receptor biology.

Basic Information

Product Name	Kainic Acid Dimethyl Ester Hydrochloride
CAS No.	108365-31-7
Molecular Formula	C12H17NO4 · HCl
Molecular Weight	275.73 g/mol (Free base: 239.27 g/mol)
Synonyms	Dimethyl Kainate Hydrochloride; Kainic Acid Dimethyl Ester HCl; (2S,3S,4S)-3-(Carboxymethyl)-4-(1-methylethenyl)-2-pyrrolidinecarboxylic Acid Dimethyl Ester Hydrochloride; Kainate Dimethyl Ester Hydrochloride; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine Dimethyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Kainic Acid Dimethyl Ester Hydrochloride is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with each batch to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.