Description

Phaclofen CAS NO 108351-35-5 is a selective and potent antagonist for the GABAB receptor, serving as a crucial research tool in neuropharmacology. Its primary value lies in its ability to block GABAB receptor-mediated responses, enabling scientists to study inhibitory neurotransmission, synaptic plasticity, and related neurological pathways. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on central nervous system disorders, pain mechanisms, and drug discovery.

Application

• Neuroscience Research: Used as a selective GABAB receptor antagonist to investigate the role of these receptors in synaptic transmission, neuronal excitability, and network behavior.
• Pharmacological Studies: A key tool compound for in vitro and ex vivo assays to characterize new GABAB receptor ligands and understand receptor function.
• Pain Research: Employed in studies exploring the involvement of GABAB receptors in nociception and the development of novel analgesic targets.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and lead optimization programs for CNS-targeted therapeutics.
• Academic & Institutional Research: Fundamental for university and research institute labs studying neurotransmitter systems, neurological disease models, and basic neurobiology.

Basic Information

Product Name	Phaclofen
CAS No.	108351-35-5
Molecular Formula	C10H12ClNO4P
Molecular Weight	291.63 g/mol
Synonyms	(3-Amino-2-(4-chlorophenyl)propyl)phosphinic acid; (R,S)-Phaclofen; 3-Amino-2-(4-chlorophenyl)propylphosphinic acid; GABAB receptor antagonist phaclofen; p-Chlorophenyl-β-aminopropylphosphinic acid; β-(p-Chlorophenyl)-γ-aminopropylphosphinic acid; Phaclofen (GABAB antagonist)
EINECS	Contact for details

Quality Control

Our Phaclofen is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.