Description

2-(Trifluoromethyl)-Pyridine-4-Carboxaldehyde is a high-value fluorinated pyridine derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both an aldehyde group and a trifluoromethyl substituent on the pyridine ring, makes it indispensable for introducing fluorinated motifs into target molecules, which can dramatically alter their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: An essential starting material for fine chemical manufacturers offering bespoke synthesis services for client-specific molecular targets.

Basic Information

Product Name	2-(Trifluoromethyl)-Pyridine-4-Carboxaldehyde
CAS No.	108338-20-1
Molecular Formula	C7H4F3NO
Molecular Weight	175.11 g/mol
Synonyms	4-Formyl-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)isonicotinaldehyde; 2-Trifluoromethylpyridine-4-carboxaldehyde; 4-Pyridinecarboxaldehyde, 2-(trifluoromethyl)-; 2-Trifluoromethyl-4-pyridinecarboxaldehyde; α,α,α-Trifluoro-2-pyridine-4-acetaldehyde; Isonicotinaldehyde, 2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)-Pyridine-4-Carboxaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are supported by comprehensive Certificates of Analysis (COA) detailing all critical parameters. We adhere to current industry best practices and can provide material suitable for research and development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in secondary opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.