Description

Nbd-Propranolol Dihydrochloride CAS NO 108321-35-3 is a chemically modified derivative of the β-blocker propranolol, featuring an NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl) fluorophore. This compound is a critical tool in pharmaceutical research and development, primarily valued for its fluorescent properties which enable advanced analytical and diagnostic applications. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity, well-characterized chemical probes for studying drug mechanisms, receptor binding assays, and cellular imaging.

Application

• Pharmaceutical Research & Development: As a fluorescently labeled analog for studying the pharmacokinetics, biodistribution, and receptor binding profiles of propranolol and related β-blockers.
• Biochemical Assays: Utilized in fluorescence polarization (FP), fluorescence resonance energy transfer (FRET), and other high-throughput screening (HTS) assays to investigate protein-ligand interactions.
• Cellular & Molecular Imaging: Serves as a fluorescent tracer in confocal microscopy and flow cytometry to visualize drug uptake and localization within cells and tissues.
• Analytical Method Development: Acts as a reference standard or an internal standard in the development and validation of sensitive analytical methods, such as HPLC with fluorescence detection or LC-MS/MS.
• Metabolic Pathway Studies: Used to trace and analyze the metabolic pathways and transformation products of propranolol in in vitro and in vivo models.
• Diagnostic Probe Development: Potential use in the development of diagnostic kits or sensors for cardiovascular research and related clinical applications.

Basic Information

Item	Details
Product Name	Nbd-Propranolol Dihydrochloride
CAS No.	108321-35-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Nitrobenz-2-oxa-1,3-diazol-4-yl Propranolol Dihydrochloride; NBD-Propranolol HCl; NBD-Labeled Propranolol Dihydrochloride; Fluorescent Propranolol Derivative; 4-(7-Nitro-2,1,3-benzoxadiazol-4-yl)propranolol Dihydrochloride; Propranolol NBD Conjugate; NBD-Propranolol
EINECS	Contact for details

Quality Control

Our Nbd-Propranolol Dihydrochloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identification (by IR, NMR), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.