Description

Calicheamicin is a potent enediyne antibiotic and antitumor agent, representing a significant class of natural products with a unique molecular architecture. Its primary value lies in its exceptional ability to cause double-strand DNA cleavage, making it a powerful payload for targeted cancer therapies, particularly in antibody-drug conjugates (ADCs). This compound is essential for pharmaceutical R&D, biotechnology firms, and academic institutions focused on oncology drug discovery and the development of next-generation bioconjugates.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead in targeted cancer therapies, where it is conjugated to monoclonal antibodies for precise tumor cell delivery.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies to investigate mechanisms of DNA damage and cell death.
• Bioconjugation Chemistry: A key molecule for developing novel linker technologies and studying the stability and efficacy of drug-antibody linkages.
• Pharmaceutical Development: Critical for the formulation and process development stages of ADC-based drug candidates.
• Biochemical Tool: Employed in molecular biology to study DNA repair pathways and genomic stability.

Basic Information

Product Name	Calicheamicin
CAS No.	108212-75-5
Molecular Formula	C55H74IN3O21S4
Molecular Weight	1368.33 g/mol
Synonyms	Calicheamicin γ1; Calicheamicin gamma 1; LL-E33288 gamma 1; L-L-E33288 gamma 1; Antibiotic LL-E33288 gamma 1; (1S,2R,3S,4S,7S,8S,11S,12R,14S,15S,17S,18S,19S)-14-[(2R,3S,6S)-3-(Dimethylamino)-6-methyloxan-2-yl]oxy-4-ethyl-3,5,7,9,11,13,15,17,19-nonahydroxy-8,18-dimethoxy-1-[(1E)-1-propen-1-yl]-10,16-dioxa-2,6-dithia-11-azoniapentacyclo[11.7.0.02,11.04,8.014,18]icosa-5,12,20-triene-12-ium-20-carboxylate; NSC 609395
EINECS	Contact for details

Quality Control

Our Calicheamicin is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support its use in critical preclinical and development activities.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The container should be kept in a dry, well-ventilated area, and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Biological Activity	Assayed (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.