Description

5-Bromothiophene-2-Sulfonyl Fluoride is a high-value, reactive organosulfur building block used in advanced chemical synthesis. Its core value lies in the sulfonyl fluoride group, which serves as a versatile handle for click chemistry and the construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of bioactive molecules, particularly for creating sulfonamide-based drugs via SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the thiophene-sulfonyl scaffold for enhanced activity.
• Polymer & Materials Science: Serves as a functional monomer or cross-linking agent for producing specialty polymers with tailored properties like conductivity or chemical resistance.
• Chemical Biology & Proteomics: Employed as a probe or labeling reagent to study enzyme activity and protein interactions due to the specific reactivity of the sulfonyl fluoride moiety.
• Ligand & Catalyst Development: Used to synthesize novel ligands and organocatalysts containing the electron-withdrawing sulfonyl fluoride group for catalytic applications.

Basic Information

Product Name	5-Bromothiophene-2-Sulfonyl Fluoride
CAS No.	108158-00-5
Molecular Formula	C4H2BrFO2S2
Molecular Weight	253.09 g/mol
Synonyms	2-Bromo-5-thiophenesulfonyl Fluoride; 5-Bromo-2-thiophenesulfonyl Fluoride; 5-Bromothiophene-2-sulfonyl fluoride; 2-Thiophenesulfonyl fluoride, 5-bromo-; Thiophene, 5-bromo-2-(fluorosulfonyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromothiophene-2-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.