Description

Kt5720 is a potent and selective cell-permeable inhibitor of protein kinase A (PKA), a key enzyme involved in numerous intracellular signaling pathways. This high-purity biochemical tool is essential for researchers and developers investigating cAMP-dependent signal transduction mechanisms in cellular models. It is particularly valuable for the pharmaceutical, biotechnology, and life science research industries, where precise modulation of PKA activity is required for drug discovery, target validation, and fundamental biological studies. The compound is supplied under stringent quality control to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: Used as a critical pharmacological tool to study the role of Protein Kinase A (PKA) in cellular processes such as metabolism, gene expression, and cell proliferation.
• Drug Discovery & Target Validation: Employed in high-throughput screening (HTS) assays and mechanistic studies to identify and validate novel therapeutic targets within the PKA signaling cascade.
• Signal Transduction Studies: Facilitates the dissection of complex cAMP/PKA-dependent pathways in neuroscience, cardiology, and endocrinology research.
• Cell Biology & Biochemistry: Applied in vitro to inhibit PKA activity in cell cultures and tissue samples, helping to elucidate specific enzyme functions.
• Academic & Institutional Research: A standard reagent in university and institutional labs for graduate and post-doctoral research projects focused on kinase biology.
• Biotech Product Development: Used in the development and quality control of assay kits and diagnostic tools related to kinase activity measurement.

Basic Information

Product Name	Kt5720
CAS No.	108068-98-0
Molecular Formula	C₃₁H₃₂N₄O₆
Molecular Weight	556.61 g/mol
Synonyms	KT 5720; KT5720; (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid hexyl ester; K-252a derivative; Protein Kinase A Inhibitor KT 5720; PKA Inhibitor KT5720
EINECS	Contact for details

Quality Control

Every batch of Kt5720 is manufactured and analyzed under strict quality management protocols to ensure the highest standards of purity and biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and potency, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Biological Activity (IC₅₀)	≤ 60 nM (vs. PKA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.