Description

2,2,2-Trifluoro-n-(6-Oxo-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-4-Yl)Acetamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused-ring structure containing both thiophene and cyclopentane motifs. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding affinity. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drugs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and pesticides, leveraging its fluorine-containing scaffold for improved efficacy.
• Material Science Research: Used in academic and industrial R&D for creating novel organic electronic materials and specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2,2,2-Trifluoro-n-(6-Oxo-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-4-Yl)Acetamide
CAS No.	108046-14-6
Molecular Formula	C9H6F3NO2S
Molecular Weight	249.21 g/mol
Synonyms	2,2,2-Trifluoro-N-(6-oxo-5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)acetamide; 4-(2,2,2-Trifluoroacetamido)-4,5-dihydro-6H-cyclopenta[b]thiophen-6-one; 108046-14-6; 4-Acetamide-6-oxo-4,5,6,7-tetrahydrocyclopenta[b]thiophene, 2,2,2-trifluoro-; N-(6-Oxo-4,5,6,7-tetrahydrocyclopenta[b]thiophen-4-yl)-2,2,2-trifluoroacetamide; TFATA Intermediate; Cyclopentathiophene Trifluoroacetamide Derivative
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(6-Oxo-5,6-Dihydro-4H-Cyclopenta[B]Thiophen-4-Yl)Acetamide is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.