Description

H-Val-Cmk·Hcl CAS NO 107831-79-8 is a specialized chloromethyl ketone derivative of the amino acid valine, widely utilized as a potent and irreversible inhibitor for serine proteases. This compound is critical for researchers and manufacturers requiring precise enzymatic control in biochemical pathways. It is primarily used in pharmaceutical research, proteomics, and the development of diagnostic assays where selective protease inhibition is necessary.

Application

• Biochemical Research: As a key tool compound for studying the mechanism and kinetics of serine proteases like trypsin, chymotrypsin, and elastase.
• Pharmaceutical Development: Used in the design and screening of novel therapeutic agents targeting protease-related diseases.
• Proteomics & Diagnostics: Employed in sample preparation and analysis to selectively inhibit proteolytic activity, preserving target proteins.
• Enzyme Characterization: Essential for determining the active site specificity and function of newly discovered proteases.
• Peptide Synthesis & Modification: Serves as an intermediate or protecting group reagent in advanced peptide chemistry.

Basic Information

Product Name	H-Val-Cmk·Hcl
CAS No.	107831-79-8
Molecular Formula	C7H13Cl2NO2
Molecular Weight	214.09 g/mol
Synonyms	L-Valyl Chloromethyl Ketone Hydrochloride; Val-CMK; H-Val-Chloromethylketone HCl; N-[(Benzyloxy)carbonyl]-L-valyl chloromethyl ketone hydrochloride; Z-Val-CMK hydrochloride; Valine chloromethyl ketone hydrochloride; Protease Inhibitor Val-CMK; (S)-2-((((Benzyloxy)carbonyl)amino)-3-methylbutanoyl chloromethyl ketone hydrochloride
EINECS	Contact for details

Quality Control

Our H-Val-Cmk·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.