Description

Calyculin B is a potent and selective marine-derived phosphatase inhibitor, primarily known for its high biological activity. This compound is a critical research tool for studying cellular signaling pathways, particularly those involving protein phosphatases 1 and 2A. It is essential for researchers and developers in the fields of biochemical research, pharmacology, and oncology. The product is supplied as a high-purity standard to ensure reliable and reproducible experimental results.

Application

• Biochemical Research: Used as a potent and specific inhibitor of protein phosphatases PP1 and PP2A in signal transduction studies.
• Cell Biology: Employed to investigate cell cycle regulation, cytoskeletal dynamics, and apoptosis.
• Pharmacology & Drug Discovery: Serves as a reference standard and a lead compound for developing novel therapeutic agents targeting phosphatase activity.
• Oncology Research: Utilized in studies exploring tumor cell growth, metastasis, and the role of phosphatases in cancer pathways.
• Neuroscience: Applied in research on synaptic plasticity, neuronal signaling, and neurodegenerative disease mechanisms.
• Academic & Institutional Laboratories: A key reagent for graduate and post-doctoral research in molecular and cellular biology.

Basic Information

Product Name	Calyculin B
CAS No.	107537-44-0
Molecular Formula	C₅₀H₈₅N₄O₁₅P
Molecular Weight	1013.2 g/mol
Synonyms	Calyculin B; (4S,7R,14S,15R,30S,33R,34S,36S,37R,38S)-37-[(2S,3S,4R,5S,6R)-4,5-Dihydroxy-3,6-dimethyl-2-(methylamino)oxan-2-yl]oxy-14,15,30,33,34,36,37,38-octahydroxy-3,4,7,8,10,11,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,33,34,36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetracontahydro-2H-15,30:33,38-diepoxy-7,14-methano-8,10,13,16,21,24,27,40,43,46-decaoxa-3,5,9,12,17,20,25,28,41,44,47-undecaazaoctatetracontaphosphinine-4-phosphonic acid; NSC 339484
EINECS	Contact for details

Quality Control

Our Calyculin B is produced under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to relevant guidelines for research-grade biochemicals to guarantee product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.