Description

2-Phenyl-2-Propyl Glucuronide is a high-purity glucuronide conjugate, a critical metabolite in drug metabolism and pharmacokinetic (DMPK) studies. This compound serves as an essential reference standard for the analysis and quantification of its parent drug or metabolite in biological matrices. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in bioanalytical method development, ADME (Absorption, Distribution, Metabolism, and Excretion) studies, and clinical trial support.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for calibrating analytical instruments in bioanalysis.
• Metabolite Identification & Quantification: Critical for quantifying Phase II glucuronidation metabolites in plasma, urine, and tissue samples during preclinical and clinical studies.
• DMPK & Toxicology Studies: Supports investigations into the metabolic fate, clearance pathways, and potential toxicity of new chemical entities.
• Bioanalytical Method Validation: Serves as a key analyte for developing and validating LC-MS/MS, HPLC-UV, or other chromatographic assays.
• Drug Impurity Profiling: Can be used to identify and control glucuronide-related impurities in active pharmaceutical ingredient (API) batches.
• Enzyme Kinetics Research: Employed as a substrate or product in studies of UDP-glucuronosyltransferase (UGT) enzyme activity and inhibition.

Basic Information

Item	Details
Product Name	2-Phenyl-2-Propyl Glucuronide
CAS No.	106760-29-6
Molecular Formula	C₁₅H₂₀O₇
Molecular Weight	312.32 g/mol
Synonyms	2-Phenylpropyl β-D-Glucopyranosiduronic Acid; 1-((2-Phenylpropan-2-yl)oxy)-β-D-glucopyranuronic acid; Phenylpropyl Glucuronide; 2-PP-Glucuronide; Glucuronide conjugate of 2-Phenyl-2-propanol; β-Glucuronidase Substrate Analog; Drug Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of 2-Phenyl-2-Propyl Glucuronide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the rigorous demands of pharmaceutical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for assay, related substances, residual solvents, and other critical parameters. Our quality commitment aligns with the standards expected for high-grade reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.