Description

Boc-[15N]Gly-Oh CAS NO 106665-75-2 is a stable isotope-labeled derivative of the amino acid glycine, specifically enriched with Nitrogen-15 at the α-amino position and protected with a tert-butoxycarbonyl (Boc) group on the amine. This compound is a critical building block for the synthesis of isotopically labeled peptides and proteins, enabling advanced research in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. It is essential for scientists in pharmaceutical R&D, academic institutions, and contract research organizations (CROs) who require precise metabolic tracing, protein structure determination, and quantitative proteomics studies.

Application

• Isotope-Labeled Peptide Synthesis: Serves as a key precursor for incorporating the 15N label into custom peptides for NMR structural analysis.
• Metabolic Pathway Tracing: Used in the preparation of isotopically labeled biomolecules to study metabolic fluxes and biochemical pathways in living systems.
• Quantitative Proteomics & Mass Spectrometry: Enables the accurate quantification of proteins and peptides when used in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) or other isotope dilution mass spec methods.
• Pharmaceutical Research: Employed in the development and characterization of novel peptide-based therapeutics and drug candidates.
• Biomolecular NMR Spectroscopy: Critical for producing 15N-labeled proteins to resolve 3D structures and study protein dynamics and interactions.
• Standards for Analytical Chemistry: Used as an internal standard for the precise quantification of glycine and related compounds in complex matrices.

Basic Information

Product Name	Boc-[15N]Gly-Oh
CAS No.	106665-75-2
Molecular Formula	C7H1415NNO4
Molecular Weight	190.18 g/mol (for 15N labeled form)
Synonyms	N-(tert-Butoxycarbonyl)-15N-glycine; (15N)-Boc-Glycine; (15N)-N-Boc-glycine; 2-[(tert-Butoxycarbonyl)(15N)amino]acetic acid; Boc-15N-Gly-OH; N-Boc-15N-glycine; tert-Butyl (15N)glycinate N-carboxylate; 15N Labeled Boc-Glycine
EINECS	Contact for details

Quality Control

Our Boc-[15N]Gly-Oh is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, critical for sensitive research applications. Each batch is analyzed via NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (typically >98 atom % 15N), and chemical purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
15N Isotopic Enrichment	≥98 atom %
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.