Description

1,1-Dioxido-4-Hydroxytetrahydrothiophene-3-Sulphonyl Chloride, also known as 3-(Chlorosulphonyl)-1,1-dioxido-4-hydroxytetrahydrothiophene, is a high-value, multi-functional sulfonyl chloride derivative and a key synthetic intermediate in advanced organic chemistry. Its reactive chlorosulfonyl group and tetrahydrothiophene dioxide backbone make it a critical building block for constructing complex molecules with specific sulfonamide or sulfonate functionalities. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors who require precise and reliable intermediates for drug discovery, active ingredient synthesis, and material science applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the introduction of the sulfonamide group can enhance biological activity and environmental profile.
• Specialty Chemical Building Block: Employed in organic synthesis for creating complex sulfonated compounds, dyes, pigments, and functional polymers.
• Bioconjugation & Probe Development: Utilized in biochemical research for labeling proteins, peptides, and other biomolecules due to its reactivity with amine groups.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers, ion-exchange resins, and advanced materials with specific ionic properties.

Basic Information

Product Name	1,1-Dioxido-4-Hydroxytetrahydrothiophene-3-Sulphonyl Chloride
CAS No.	106508-20-7
Molecular Formula	C4H7ClO5S2
Molecular Weight	234.68 g/mol
Synonyms	3-(Chlorosulfonyl)-4-hydroxy-1,1-dioxotetrahydrothiophene; 4-Hydroxy-1,1-dioxotetrahydrothiophene-3-sulfonyl chloride; Tetrahydrothiophene-3-sulfonyl chloride, 4-hydroxy-1,1-dioxide; 1,1-Dioxo-4-hydroxytetrahydrothiophene-3-sulfonyl chloride; 3-Chlorosulfonyl-4-hydroxy-tetrahydrothiophene 1,1-dioxide; 4-Hydroxytetrahydrothiophene-3-sulfonyl chloride 1,1-dioxide; THF-sulfonyl chloride derivative
EINECS	Contact for details

Quality Control

Our 1,1-Dioxido-4-Hydroxytetrahydrothiophene-3-Sulphonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.