Description

3-Oxa-9(O)-Methano-Delta(6,9)Prostaglandin I(1) is a synthetic prostaglandin I1 (PGI1) analog, a key structural derivative of prostacyclin. This compound is valued for its potent biological activity and serves as a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutics targeting cardiovascular and pulmonary systems.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel prostacyclin analogs and related therapeutic agents.
• Cardiovascular Research: Used in preclinical studies to investigate vasodilation, platelet aggregation inhibition, and vascular homeostasis.
• Pulmonary Hypertension Drug Development: Serves as a reference compound or precursor in the development of treatments for pulmonary arterial hypertension (PAH).
• Biochemical Research: Employed as a tool compound to study prostaglandin receptors (IP receptor) and related signaling pathways.
• Process Chemistry: Utilized in route scouting and optimization for the commercial-scale production of prostaglandin-based APIs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	3-Oxa-9(O)-Methano-Delta(6,9)Prostaglandin I(1)
CAS No.	106402-09-9
Molecular Formula	C₂₁H₃₂O₅
Molecular Weight	364.48 g/mol
Synonyms	9-O-Methano-δ⁶⁹α-PGI₁; 3-Oxa-9α-methano-δ⁶⁹α-PGI₁; 9α-Methano-δ⁶⁹α-PGI₁; 3-Oxa-PGI₁ analog; 9-Methanoprostacyclin derivative; 6,9-Methano-PGI₁; Iloprost intermediate; Prostaglandin I1 analog
EINECS	Contact for details

Quality Control

Our 3-Oxa-9(O)-Methano-Delta(6,9)Prostaglandin I(1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled temperature of -20°C or below to minimize oxidation and ensure long-term stability. The container should be kept in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.