Description

1,25-Dihydroxy-26,27-Dipropylcholecalciferol is a synthetic analog of the biologically active form of vitamin D, specifically engineered with propyl side chains at the 26 and 27 positions. This structural modification is significant for enhancing metabolic stability and receptor binding affinity, making it a valuable research compound. It is primarily utilized in advanced biochemical and pharmacological research focused on vitamin D receptor (VDR) signaling pathways, calcium homeostasis, and cell differentiation studies.

Application

• Biochemical Research: A key tool for investigating the structure-activity relationships (SAR) of vitamin D analogs and their interaction with the Vitamin D Receptor (VDR).
• Pharmacological Studies: Used in preclinical research to explore potential therapeutic applications related to bone metabolism, immune modulation, and cellular proliferation.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in the synthesis of novel vitamin D derivatives.
• Metabolic Pathway Analysis: Employed in studies to understand the catabolism and tissue-specific effects of modified secosteroids.

Basic Information

Product Name	1,25-Dihydroxy-26,27-Dipropylcholecalciferol
CAS No.	106372-51-4
Molecular Formula	C₃₀H₅₀O₃
Molecular Weight	458.72 g/mol
Synonyms	1,25-Dihydroxy-26,27-dipropylvitamin D3; 26,27-Dipropyl-1,25-dihydroxycholecalciferol; 1α,25-Dihydroxy-26,27-dipropylcholesta-5,7,10(19)-trien-3β-ol; Ro 23-6010; 1,25(OH)₂-26,27-dipropyl-D₃; KH 1060 (Note: KH 1060 is a closely related analog; verify specific structure for this CAS).
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-26,27-Dipropylcholecalciferol is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant guidelines for research-grade chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.