Description

2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-4-Phosphono-Butanoic Acid is a high-purity, advanced pharmaceutical intermediate with a complex molecular structure. This compound is critical for research and development in targeted therapeutic areas, particularly in the synthesis of novel antifolate agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and fine chemical manufacturers engaged in the development of enzyme inhibitors and precision medicines.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antifolate drugs and enzyme inhibitors.
• Biochemical Research: Used as a reference standard or active compound in studies targeting dihydrofolate reductase (DHFR) and related enzymatic pathways.
• Preclinical Development: Serves as a crucial material for pharmacokinetic, pharmacodynamic, and toxicology studies in drug discovery pipelines.
• Anticancer Agent Research: Investigated for its potential role in the development of chemotherapeutic agents due to its structural similarity to known antifolates.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-4-Phosphono-Butanoic Acid
CAS No.	106351-99-9
Molecular Formula	C19H22N8O6P
Molecular Weight	489.40 g/mol
Synonyms	4-Phosphono-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]butanoic acid; 2-{N-[4-((2,4-Diaminopteridin-6-yl)methylamino)benzoyl]amino}-4-phosphonobutanoic acid; PT523; Pteroic acid-γ-phosphonate-glutamate analog; Antifolate phosphonate derivative; NSC 721781; DAP-PT523; γ-Phosphono Pteroate Glutamate
EINECS	Contact for details

Quality Control

Our 2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-4-Phosphono-Butanoic Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade and cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.