Description

1,25-Dihydroxy-21-Nor-20-Oxavitamin D3 is a synthetic analog of the active form of vitamin D, specifically designed for research and development in the life sciences. This compound is significant for its role in studying vitamin D receptor (VDR) signaling pathways and metabolism without the full calcemic effects of the native hormone. It is primarily needed by pharmaceutical R&D teams, academic researchers, and manufacturers of high-purity biochemical reagents focused on endocrinology, bone health, and oncology research.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate for developing novel vitamin D receptor modulators.
• Biochemical Research: Used as a potent tool compound to investigate VDR-mediated gene expression, cell differentiation, and immune system regulation in vitro and in vivo.
• Metabolic Studies: Employed in studies of calcium and phosphate homeostasis, particularly for research into conditions like osteoporosis and chronic kidney disease.
• Oncology Research: Investigated for its potential anti-proliferative and pro-differentiation effects on various cancer cell lines.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and quality control in laboratories.
• Life Science Reagents: A critical component in the formulation of specialized cell culture media and diagnostic assay kits.

Basic Information

Product Name	1,25-Dihydroxy-21-Nor-20-Oxavitamin D3
CAS No.	106315-28-0
Molecular Formula	C₂₆H₄₀O₄
Molecular Weight	416.59 g/mol
Synonyms	21-Nor-1,25-dihydroxy-20-oxavitamin D3; 1,25-Dihydroxy-21-nor-20-oxocholecalciferol; 21-Nor-1α,25-dihydroxy-20-oxovitamin D3; 1α,25-Dihydroxy-21-nor-20-oxovitamin D3; 21-Nor-20-oxo-1α,25-dihydroxyvitamin D3; 21-Nor-20-oxocalcitriol analog; KH 1060 (research code); A vitamin D receptor agonist analog.
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-21-Nor-20-Oxavitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.