Description

2-(Azidomethyl)-1,3-Difluorobenzene is a specialized aromatic building block featuring both azide and fluorine functional groups, enabling advanced synthetic transformations. This compound is valued for its role as a key precursor in click chemistry and bioorthogonal labeling applications, facilitating efficient and selective molecular assembly. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A versatile synthon for the synthesis of novel drug candidates, particularly through Huisgen 1,3-dipolar cycloaddition (click chemistry) to create triazole linkages.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluorobenzene moiety can enhance biological activity and metabolic stability.
• Materials Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced materials with tailored properties.
• Bioconjugation & Probe Synthesis: Essential for labeling biomolecules (proteins, antibodies, nucleic acids) with fluorescent dyes or other reporter groups for diagnostic and imaging applications.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and other probe-based strategies to study enzyme function and discover new targets.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing novel ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-(Azidomethyl)-1,3-Difluorobenzene
CAS No.	106308-60-5
Molecular Formula	C7H5F2N3
Molecular Weight	169.13 g/mol
Synonyms	1,3-Difluoro-2-(azidomethyl)benzene; 2-(Azidomethyl)-1,3-difluorobenzene; α-Azido-2,6-difluorotoluene; (Azidomethyl)-2,6-difluorobenzene; 2,6-Difluorobenzyl azide; 1-(Azidomethyl)-2,4-difluorobenzene; Benzene, 1,3-difluoro-2-(azidomethyl)-
EINECS	Contact for details

Quality Control

Our 2-(Azidomethyl)-1,3-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.