Description

1-n-Palmitoylkanamycin A is a chemically modified derivative of the aminoglycoside antibiotic kanamycin A, where a palmitoyl group is attached to the 1-amino position. This modification is designed to alter the compound's physicochemical properties, potentially enhancing its lipophilicity, membrane permeability, and biological activity profile. It is primarily of interest to researchers and developers in the pharmaceutical and biotechnology sectors for applications in drug discovery, antimicrobial research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active compound in the synthesis and screening of novel antibiotic candidates.
• Antimicrobial Mechanism Studies: Used as a tool compound to investigate structure-activity relationships (SAR) and the impact of lipophilic modifications on aminoglycoside efficacy.
• Bioconjugation & Prodrug Development: Acts as a model substrate for developing targeted drug delivery systems or prodrug strategies to improve pharmacokinetics.
• Biochemical Research: Employed in studies exploring bacterial ribosome interaction, resistance mechanisms, and the development of next-generation anti-infectives.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1-n-Palmitoylkanamycin A
CAS No.	106190-43-6
Molecular Formula	C42H81N5O15
Molecular Weight	896.11 g/mol
Synonyms	Kanamycin A 1-Palmitate; 1-Palmitoylkanamycin A; N1-Palmitoylkanamycin A; Kanamycin A Palmitoyl Ester; Palmitoyl Kanamycin A Derivative; O-1-Palmitoylkanamycin; 6-O-(2-Amino-2-deoxy-α-D-glucopyranosyl)-4-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-1-N-hexadecanoyl-2-deoxystreptamine
EINECS	Contact for details

Quality Control

Our 1-n-Palmitoylkanamycin A is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Assay (on dried basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.