Description

D-Glucose-6-13C is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 6th position. This precise labeling is critical for advanced metabolic research, enabling scientists to trace glucose utilization and metabolic pathways with high specificity using techniques like NMR spectroscopy and mass spectrometry. It is an essential tool for researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors, particularly for studies in diabetes, cancer metabolism, and carbohydrate biochemistry.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates in cell cultures and tissues.
• Drug Metabolism Studies: Employed in pharmaceutical R&D to investigate the metabolic fate of new drug candidates and their interaction with glucose pathways.
• Clinical Research: Serves as a diagnostic probe in human and animal studies to understand disorders of glucose metabolism, such as insulin resistance and cancer.
• NMR Spectroscopy: Acts as a standard and substrate for 13C-NMR studies due to its specific isotopic enrichment, providing clear spectral signals.
• Mass Spectrometry (MS) Standards: Used as an internal standard for the accurate quantification of glucose and its metabolites in complex biological samples via GC-MS or LC-MS.
• Biochemical Research: Fundamental substrate for enzymatic studies involving hexokinase, glucose-6-phosphate dehydrogenase, and other glycolytic enzymes.

Basic Information

Product Name	D-Glucose-6-13C
CAS No.	106032-62-6
Molecular Formula	C512C13H12O6
Molecular Weight	181.15 g/mol (for 13C1 isotopologue)
Synonyms	D-(+)-Glucose-6-13C; 6-13C-Glucose; Dextrose-6-13C; D-Glucose (6-13C); (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-6-13C; D-Glc-6-13C; Glucose-6-13C; D-Glucose-6-13C monohydrate (common form); D-Glucose (U-13C6) is a related compound.
EINECS	Contact for details

Quality Control

Our D-Glucose-6-13C is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high isotopic and chemical purity, with specifications typically meeting or exceeding research-grade standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity (by HPLC), and identity confirmation (by NMR/IR) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.