Description

5-(Bromomethyl)-2-Fluoropyridine is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a fluorine substituent, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in catalysis and material science.
• Functional Material Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The bromomethyl group is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Fluorine Chemistry Exploration: A valuable substrate for studying the effects of fluorine introduction on the bioactivity and physicochemical properties of molecules.

Basic Information

Product Name	5-(Bromomethyl)-2-Fluoropyridine
CAS No.	105827-74-5
Molecular Formula	C6H5BrFN
Molecular Weight	190.01 g/mol
Synonyms	2-Fluoro-5-(bromomethyl)pyridine; 5-(Bromomethyl)-2-fluoropyridine; 2-Fluoro-5-bromomethylpyridine; (2-Fluoropyridin-5-yl)methyl bromide; 2-Fluoropyridine-5-methyl bromide; 5-Bromomethyl-2-fluoropyridine; 2-Fluoro-5-(bromomethyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-2-Fluoropyridine is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our production adheres to cGMP standards where applicable, ensuring consistency and reliability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.