Description

26-Homo-1,25-Dihydroxyvitamin D3 is a synthetic analog of the biologically active form of vitamin D, designed for advanced research and development applications. This compound is valued for its specific structural modifications, which allow scientists to probe and modulate vitamin D receptor (VDR) signaling pathways with high precision. It is primarily utilized by pharmaceutical researchers, academic institutions, and fine chemical manufacturers engaged in endocrinology, oncology, and metabolic disease studies.

Application

• Pharmaceutical Research & Development: As a key reference standard and synthetic intermediate in the development of novel vitamin D receptor modulators for treating osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Biochemical Studies: Used to investigate the structure-activity relationships (SAR) of vitamin D analogs and their interaction with the VDR in cell-based assays and binding studies.
• Metabolic Pathway Analysis: A critical tool for studying calcium and phosphate homeostasis, cell differentiation, and immune system regulation in preclinical models.
• Fine Chemical Synthesis: Serves as a high-value building block for the custom synthesis of more complex, targeted vitamin D analogs and prodrugs.
• Reference Material: Employed as an analytical standard in HPLC and LC-MS methods for quality control and quantification of vitamin D metabolites in various matrices.

Basic Information

Product Name	26-Homo-1,25-Dihydroxyvitamin D3
CAS No.	105687-81-8
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.65 g/mol
Synonyms	26,27-Dinor-1,25-dihydroxycholecalciferol; 26-Homo-calcitriol; 1α,25-Dihydroxy-26,27-dinorcholecalciferol; 26-Homo-1α,25-dihydroxyvitamin D₃; 26,27-Dinor-1α,25-(OH)₂D₃; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol (homolog); EB 1089 precursor analog
EINECS	Contact for details

Quality Control

Our 26-Homo-1,25-Dihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, purity, and consistency for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.