Description

10-Demethyl-10-(Methoxycarbonyl)-25-Demethyl-2,25-Epithio-2,5-Dihydro-5,21-Dihydroxy-19-o-Methylprotostreptovaricin I is a structurally complex ansamycin derivative, representing a key intermediate and reference standard in advanced pharmaceutical research and development. Its significance lies in its role as a precursor or analog for novel therapeutic agents, particularly in the exploration of new antibiotics and antitumor compounds. This high-purity chemical is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing next-generation treatments targeting resistant bacterial strains and oncological pathways.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for quality control, method validation, and regulatory submissions in drug development.
• Antibiotic Research Intermediate: Used as a key synthetic intermediate or building block in the research and development of new ansamycin-class antibiotics.
• Oncology Drug Discovery: Investigated as a precursor or analog in the synthesis of novel compounds targeting specific cancer cell mechanisms.
• Biochemical Research: Employed in studies of enzyme inhibition, molecular biology pathways, and structure-activity relationship (SAR) analysis.
• Process Chemistry & Scale-Up: Utilized in process development and optimization for the commercial-scale synthesis of related active pharmaceutical ingredients (APIs).
• Academic Research: A vital tool for universities and research institutes studying natural product synthesis, medicinal chemistry, and microbial resistance.

Basic Information

Item	Detail
Product Name	10-Demethyl-10-(Methoxycarbonyl)-25-Demethyl-2,25-Epithio-2,5-Dihydro-5,21-Dihydroxy-19-o-Methylprotostreptovaricin I
CAS No.	105645-37-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	19-O-Methylprotostreptovaricin I derivative; Ansamycin derivative; Protostreptovaricin I analog; 2,25-Epithio-2,5-dihydro-5,21-dihydroxy-19-O-methylprotostreptovaricin I; 10-Demethyl-10-methoxycarbonyl-25-demethylprotostreptovaricin I derivative; CAS 105645-37-2; Streptovaricin complex derivative
EINECS	Contact for details

Quality Control

Our 10-Demethyl-10-(Methoxycarbonyl)-25-Demethyl-2,25-Epithio-2,5-Dihydro-5,21-Dihydroxy-19-o-Methylprotostreptovaricin I is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (typically 15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to ensure maximum stability. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.