Description

Z-Fa-Fmk is a potent and selective fluoromethyl ketone-based inhibitor of cysteine proteases, particularly caspases. This compound is a critical research tool for studying programmed cell death (apoptosis) and inflammatory pathways. It is essential for researchers and developers in pharmaceutical discovery, biochemistry, and cell biology who require high-purity biochemical reagents for mechanistic studies and assay development.

Application

• Biochemical Research: Used as a specific, irreversible inhibitor to study the role of caspases in apoptotic signaling pathways.
• Pharmaceutical Screening: Serves as a reference standard and positive control in high-throughput screening assays for novel anti-apoptotic drug candidates.
• Cell Biology Studies: Employed to inhibit caspase activity in cell cultures to elucidate the mechanisms of cell death in neurodegenerative diseases, ischemia, and immune disorders.
• Protease Characterization: A key tool for characterizing the substrate specificity and kinetics of various cysteine proteases in vitro.
• Inflammation Research: Applied in models of inflammatory disease to investigate caspase-mediated processes like pyroptosis.

Basic Information

Product Name	Z-Fa-Fmk
CAS No.	105637-38-5
Molecular Formula	C22H23FN2O6
Molecular Weight	430.43 g/mol
Synonyms	Z-FA-FMK; Z-FA-FMK Caspase Inhibitor; Z-Phe-Ala-FMK; Benzyloxycarbonyl-Phe-Ala-fluoromethyl ketone; Caspase Inhibitor Z-FA-FMK; Z-FA-Fluoromethyl Ketone; Z-FA-FMK (Caspase Inhibitor); N-Benzyloxycarbonyl-L-phenylalanyl-L-alanine fluoromethyl ketone
EINECS	Contact for details

Quality Control

Every batch of Z-Fa-Fmk is manufactured and tested under strict quality management protocols to ensure identity, purity, and activity. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.